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Update Shipping. If taken with a high-fat meal, absorption is reduced; the time taken to reach the maximum plasma concentration increases by around one hour, and the maximum concentration itself is decreased by nearly one-third.

There are also mouth spray preparations of sildenafil for faster onset of action. The preparation steps for synthesis of sildenafil are: [49].

Sildenafil compound UK, was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent , research facility in England.

It was initially studied for use in hypertension high blood pressure and angina pectoris a symptom of ischaemic heart disease.

The first clinical trials were conducted in Morriston Hospital in Swansea. Numerous sites on the Internet offer Viagra for sale after an "online consultation", often a simple web questionnaire.

Viagra is also informally known as "vitamin V", "the blue pill", or "blue diamond", as well as various other nicknames. In February , it was announced that Boots , the UK pharmacy chain, would try over-the-counter sales of Viagra in stores in Manchester , England.

Men between the ages of 30 and 65 would be eligible to buy four tablets after a consultation with a pharmacist. While the sale remains subject to a consultation with a pharmacist, the other restrictions from the trial have been removed, allowing customers over the age of 18 to purchase an unlimited number of pills [67] The decision was made, in part, to reduce online sales of counterfeit and potentially dangerous erectile dysfunction treatments.

On 6 May , Pfizer , which manufactures Viagra, told The Associated Press they will begin selling the drug directly to patients on its website.

Pfizer's patents on Viagra expired outside the US in ; in the US they were set to expire, but Pfizer settled litigation with each of Mylan and Teva which agreed that both companies could introduce generics in the US on 11 December As of , the U.

Food and Drug Administration has approved 15 drug manufacturers to market generic sildenafil in the United States.

Seven of these companies are based in India. This is likely to lead to dramatic price reductions. Counterfeit Viagra, despite generally being cheaper, [75] can contain harmful substances or substances that affect how Viagra works, such as blue printer ink, amphetamines , metronidazole , boric acid , and rat poison.

Viagra is one of the world's most counterfeited medicines. There were 2,, prescriptions for Sildenafil in in England, compared with 1,, in In , Viagra Connect, a particular formulation of Sildenafil marketed by Pfizer, became available for sale without a prescription in the UK, [67] in an attempt to widen availability and reduce demand for counterfeit products.

Sildenafil is available as a generic drug in the United States, labelled for pulmonary arterial hypertension. In the United States, Pfizer received two patents for sildenafil: one for its indication to treat cardiovascular disease marketed as Revatio and another for its indication to treat erectile dysfunction marketed as Viagra.

The substance is the same under both trade names. In , Pfizer filed a patent covering the substance sildenafil and its use to treat cardiovascular diseases.

The patent was published in and expired in The patent on Revatio indicated for pulmonary arterial hypertension rather than erectile dysfunction expired in late Generic versions of this low-dose form of sildenafil have been available in the U.

In , Pfizer filed a patent covering the use of sildenafil to treat erectile dysfunction. This patent was published in and will expire in Teva sued to have the latter patent invalidated, but Pfizer prevailed in an August federal district court case.

In Canada , Pfizer's patent 2,, for Revatio sildenafil used to treat pulmonary hypertension was found invalid by the Federal Court in June , on an application by Ratiopharm Inc.

On 8 November , the Supreme Court of Canada ruled that Pfizer's patent 2,, on Viagra was invalid from the beginning because the company did not provide full disclosure in its application.

The decision, Teva Canada Ltd. Pfizer Canada Inc. It added further: "As a matter of policy and sound statutory interpretation, patentees cannot be allowed to 'game' the system in this way.

This, in my view, is the key issue in this appeal. Manufacture and sale of sildenafil citrate drugs known as "generic Viagra" is common in India , where Pfizer's patent claim does not apply.

Manufacture and sale of sildenafil citrate drugs is common in China , where Pfizer's patent claim is not widely enforced.

Sildenafil was reclassified in New Zealand in so it could be bought over the counter from a pharmacist. It is thought that this reduced sales over the Internet and was safer as men could be referred for medical advice if appropriate.

Egypt approved Viagra for sale in , but soon afterwards allowed local companies to produce generic versions of the drug, citing the interests of poor people who would not be able to afford Pfizer's price.

Pfizer's patent on sildenafil citrate expired in Brazil in From Wikipedia, the free encyclopedia. For other uses, see Viagra disambiguation. IUPAC name.

Interactive image. Further information: Counterfeit medications. Retrieved 6 October European Medicines Agency.

British Journal of Clinical Pharmacology. Retrieved 1 December Sexual Medicine Reviews. Retrieved 11 April CBS News. Retrieved 24 November Follow Suit?

Centers for Medicare and Medicaid Services. Respiratory Medicine. Retrieved 5 November Annals of the Rheumatic Diseases.

PDE-5 inhibitors appear to have significant but moderate efficacy in secondary [Raynaud's phenomenon]. Phosphodiesterase inhibitors e.

Commonly-used classes of drugs". Cochrane Database of Systematic Reviews. Food and Drug Administration. Archived from the original on 22 October Drug Safety.

The American Journal of Cardiology. Journal of the American College of Cardiology. Retrieved 11 July

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Follow your doctor's instructions. During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away.

You could be having a serious side effect of sildenafil. Viagra dosage information in more detail. Grapefruit and grapefruit juice may interact with sildenafil and lead to unwanted side effects.

Avoid the use of grapefruit products while taking sildenafil. Avoid using any other medicines to treat impotence, such as alprostadil or yohimbine, without first talking to your doctor.

Get emergency medical help if you have signs of an allergic reaction to Viagra: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Viagra side effects in more detail. Do not take Viagra with similar medications such as avanafil Stendra , tadalafil Cialis or vardenafil Levitra.

Tell your doctor about all other medications you use for erectile dysfunction. This list is not complete.

Other drugs may interact with sildenafil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Viagra drug interactions in more detail. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Viagra only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Other brands: Revatio. Staxyn , Stendra , Muse , Cialis. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

Available for Android and iOS devices. Subscribe to Drugs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

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